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KMID : 0043320070300070816
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Archives of Pharmacal Research
2007 Volume.30 No. 7 p.816 ~ p.819
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Isocoumarin Derivatives from the Sea Squirt-derived Fungus Penicillium stoloniferum QY2-10 and the Halotolerant Fungus Penicillium notatum B-52
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Xin Zhi-Hong
Fang Yu-chun
Gu Qian-Qun
Zhu Wei-Ming
Li-Tian
Zhu Tian-jiao
Wang Wen-Liang
Du Lin
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Abstract
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Two isocoumarin derivatives, stoloniferol A (1) and B (2), a known 5? 8?epidioxy-23-methyl- (22E, 24R)-ergosta-6, 22-dien-3?ol (3), and a known dihydrocitrinone (4) were isolated from the ethyl acetate extract of the sea squirt-derived fungus, Penicillium stoloniferum QY2-10, and a halophilic fungus, Penicillium notatum B-52, respectively. Their structures were elucidated by spectroscopic methods and optical rotation. The stereochemistry of 2 was determined on the basis of different NOE experiments and chemical transformation. Compound 3 showed cytotoxicity against P388 cells, with an IC50 value of 4.07 μM.
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KEYWORD
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Sea squirt-derived fungus, Penicillium stoloniferum, Halotolerant fungus, Penicillium notatum, Stoloniferol A and B
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